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USP22 ubiquitinates SIRT1. 11 / 11
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"USP22 negatively regulates STAT signaling by deubiquitinating SIRT1 in colon cancer cells [15] ."
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"USP22 negatively regulates STAT signaling by deubiquitinating SIRT1 [15] ."
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"As shown in the data in Fig. 3 B, USP22-FLAG rather than USP22–C185S-FLAG could reduce the Sirt1 ubiquitination level, indicating that the USP22 plasmids functioned normally in the EMT model."
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"Sirt1 ubiquitination can be modulated by USP22, MDM2 and JNK proteins (Gao et al. 2011; Peng et al. 2015; Xiong et al. 2017)."
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"For example, Lin et al. (2012) proposed that USP22 can suppress TP53 transcriptional activation by deubiquitinating SIRT1 ."
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"Third, since USP7 has key roles in the p53 tumor suppressor pathway through stabilization of p53 via increasing MDM2 [6, 52], while USP22 is reported to antagonize p53 transcriptional activation by deubiquitinating Sirt1 to suppress [34], we further investigated p53p53 the effect of USP22 and USP7 inhibition on the p53 pathway."
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"Additionally, by deubiquitinating Sirt1, the increased expression of USP22 decreased the frequency of p53-dependent apoptosis and oxidative response (Figures 5, 6)."
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"Recent studies have found that USP22 negatively regulates STAT signaling and p53 activation [9] by deubiquitinating Sirt1 [15,16] ."
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"Meanwhile, USP22 may also antagonize p53 transcriptional activation by deubiquitinating and stabilizing Sirt1 [14] ."
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"Furthermore, previous studies have revealed that Sirt1 ubiquitination can be modulated by ubiquitin specific peptidase 22 (USP22), mouse double minute 2 homolog (MDM2) and c-Jun N-terminal kinase (JNK) proteins (Gao et al. 2011; Peng et al. 2015; Xiong et al. 2017)."
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"14 As expected, USP22 inhibition increased, while USP22 overexpression decreased the abundance of SIRT1 ubiquitination (Figure 5H)."
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