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Statements

USP18 activates Protease. 3 / 3
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"A similar role of RNAse L negative regulation of the IFN response has also been suggested by the report that a novel IFN-stimulated gene encoding a 43-kDa ubiquitin-specific protease, designated ISG43[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A novel interferon stimulated gene encoding a 43-kDa ubiquitin specific protease, designated ISG43, was identified in this screen."
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"The IFN-stimulated gene ubiquitin-specific proteinase 18 (USP18) encodes a protein that negatively regulates T1 IFN signaling via stearic inhibition of JAK1 recruitment to the IFN-alpha receptor 2 subunit (IFNAR2)."
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