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BAP1 increases the amount of IL1B. 4 / 4
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"Rucavado et al. [14] have demonstrated that the intramuscular injection of the SVMP, BaP1, from B. asper venom produced notable tissue alterations and increases in the protein levels of IL-1β, IL-6, a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This study showed that the snake venom metalloprotease (SVMP) BaP1 activates FLSs to produce PGE 2 by a mechanism dependent on COX-2, mPGES-1 and iPLA 2 s. BaP1 also induces IL-1beta release, which up-regulates the production of PGE 2 at a late stage of the stimulation."
32094439
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"Partially consistent with our results, BAP1 was unfolded to increase the COX-2 and mPGES-1 expression by activating the NF-κB signaling pathway and inducing the release of IL-1β (Viana et al. 2020), but this study failed to explore the regulatory role of BAP1 mutations on the NF-κB signaling pathway."
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"Taken together, our findings show that the metalloprotease BaP1 directly activates FLSs to produce PGE by a COX-2-dependent mechanism involving the coupling of the inducible enzymes COX-2 and mPGES-1 and intracellular PLA s. BaP1 also induced release of IL-1β, which up-regulates the production of PGE at a later stage of the stimulation."
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