IndraLab

Statements

USP32 activates signal transduction. 4 / 4
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"These experimental results suggest that USP32 activates the RAF/MEK/ERK signaling pathway, which in turn promotes NSCLC cell proliferation, migration, and EMT progression through deubiquitination and stabilization of BAG3."
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"Additionally, USP32 promotes GC cell growth, metastasis, and chemoresistance by upregulating SMAD2, an important protein in the TGF-β signaling pathway [55]."
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"In summary, these findings support our theory that USP32 regulates the level of BAG3 protein to activate the RAF/MEK/ERK signaling pathway."
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"In conclusion, our study has found that USP32 promotes CRC development by activating the NF‐κB signalling pathway, and the USP32 –NF‐κB axis may act as a potential target for CRC therapy."
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