IndraLab

Statements

KCNA1 activates KCN. 2 / 2
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"Episodic ataxia type 1 (EA1) is caused by mutations in the KCNA1 gene encoding the fast potassium channel Kv1.1 and is characterized clinically by brief episodes of ataxia and continuous and spontaneous motor unit activity."
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"Despite this limitation, the current literature provides evidence that even in channelopathies with central nervous system symptoms, like seizures in the case of voltage-dependent Na channel β-subunit mutation [9] and episodes of ataxia caused by Kv1.1 fast potassium channel dysfunction [12,13,14], complex changes in excitability can be studied using an NES and that mutation carriers can be distinguished from healthy individuals."
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