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USP8 decreases the amount of FZR1. 2 / 2
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"Second, we found that compared to the control, both USP8 mutation in the Bombyx PSG and USP8 knockdown in the Drosophila salivary gland substantially reduced the Fzr protein level (Fig. 2, C and D) but did not alter Fzr mRNA expression (fig."
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"Notably, in vivo ubiquitination assays showed that USP8 depletion in the Bombyx PSGs and Drosophila salivary glands increased Fzr ubiquitination levels (Fig. 2, F and G, and fig."
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