IndraLab

Statements

EC 3.5.1.98 (histone deacetylase) inhibitor inhibits STAT1. 5 / 5
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"Butyrate, produced by numerous commensal bacteria (i.e., Faecalibacterium, Coprococcus, Roseburia, Eubacterium) from dietary fiber, is an anti-inflammatory HDAC inhibitor by inhibiting the STAT1 and NF-kB activation [139]."
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"HDACi exposure of primary blood cells fails to induce caspase activation and STAT1 reduction."
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"HDACi prevent the removal of acetyl groups from lysine residues by histone deacetylases (HDACs), increase STAT1 acetylation and inhibit STAT1 signaling [25]."
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"Hence, HDACi likely attenuate p53 levels independent of STAT1 (Supplemental Fig. S2)."
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"Likewise, treatment with the HDAC inhibitor trichostatin A potently inhibited ISGF3 transcriptional activity (Figure 6I), but no effect was observed for H2A.Z in ChIP assay (Figure 6J), ruling out class I and II HDACs in this process."
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