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USP4 deubiquitinates CTNNB1. 10 / 11
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"In addition, β-catenin is deubiquitinated by USP15 and USP4 [ 38 , 39 ]."
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"In addition, USP4 enhances the Wnt signaling pathway and regulates osteogenic differentiation by deubiquitinating and stabilizing β-catenin [43]."
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"In a colon cancer cell line, USP4 deubiquitinates beta-catenin and mediates its nuclear transportation, thus promoting Wnt and beta-catenin signaling and cancer cells growth, migration, and invasion."
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"USP4 activates the Wnt/β-catenin signaling pathway by promoting the deubiquitination of β-catenin (Yun et al., 2015)."
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"Moreover, a Korean study also indicated that USP4 was a positive modulator of Wnt/β-catenin signaling pathway by deubiquitinating and facilitating nucleus localization of β-catenin and then promoted i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We showed that USP4 deubiquitinates beta-catenin."
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"Moreover, USP4 contributes to the progression of CRC by deubiquitinating and controlling the stability of β-catenin, a key component of the Wnt/β-catenin pathway[56]."
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"Ubiquitin-specific protease 4 (USP4) is highly overexpressed in colon cancer and acts as a potent protooncogenic protein by deubiquitinating β-catenin."
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"USP4 deubiquitinates and stabilizes β-catenin to drive colon cancer cell migration [29]."
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"Deubiquitination of beta-catenin by USP4 reverses the ubiquitination mediated degradation of beta-catenin, upregulating Wnt signalling."
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