IndraLab

Statements

CTSK leads to the phosphorylation of OTUB1. 2 / 2
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"Similar results were also observed in siRNA-mediated knockdown of cathepsin K. Cathepsin K siRNA decreased Raptor protein expression and phosphorylation of OTUB1 and Src in Caki-1 (renal carcinoma), A549 (lung carcinoma), and DU145 (prostate carcinoma) cells, significantly (Fig. 1B)."
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"Moreover, inhibition of cathepsin K (by ODN and siRNA) significantly increased SHP2 phosphorylation at Y542, and SHP2 inhibition (by using pharmacological inhibitor and siRNA) interrupted the ODN-mediated dephosphorylation of OTUB1 and Src, eventually stabilizing Raptor (Fig. 2C–F)."
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