IndraLab

Statements

USP18 inhibits ubiquitination. 13 / 13
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sparser
"USP18 inhibits the K63-linked ubiquitination of TAK1 in a protease-dependent manner."
26240016
sparser
"USP18 inhibits the conjugated K63-linked ubiquitination of NEMO in a protease-independent manner."
26240016
sparser
"Conversely, USP18 inhibited NEMO ubiquitination by directly binding to its UBAN motif (ubiquitin binding in ABIN and NEMO) and masking its ubiquitination sites at Lys 325 and 326 from further K63-linked ubiquitination."
26240016
sparser
"On the other hand, USP18 inhibits NEMO ubiquitination by directly binding to its UBAN domain."
26240016
sparser
"We next tested whether USP18 inhibited NEMO ubiquitination through USP18 protease activity."
26240016
sparser
"USP18 inhibits NEMO ubiquitination at the Lys -325 and 326 sites by masking the UBAN domain of NEMO."
26240016
sparser
"In contrast, they suggest that USP18 inhibits ubiquitination of the TAK1/TAB1 complex in a protease dependent manner xref , xref ."
28165509
sparser
"This suggests that USP18 may specifically inhibit the K63-linked ubiquitination of NEMO at the Lys −325 and −326 sites."
26240016
sparser
"Our results demonstrated that USP18 inhibits covalently conjugated K63-linked ubiquitination of NEMO but had little or no effects on the linear (M1) ubiquitination of NEMO."
26240016
sparser
"USP18 can inhibit the ubiquitination of the TAK1-TAB complex, thereby inhibiting IL-2 production and promoting IL-17 production and synthesis."
27809302
sparser
"Collectively, our findings revealed that USP18 inhibits TAK1 and NEMO ubiquitination through different mechanisms."
26240016
sparser
"USP18 inhibits the K63-linked ubiquitination of TAK1 and NEMO through distinct mechanisms ( xref )."
26240016
sparser
"We found that USP18 could further inhibit K63-linked ubiquitination of NEMO in the presence of IsoT ( xref ), suggesting that USP18 primarily blocked the linkage of conjugated K63-linked polyubiquitin chains on NEMO."
26240016