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ATP inhibits NLRP3. 77 / 77
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"Treatment with iptakalim, a novel ATP-sensitive potassium channel opener, ameliorated the behavioral effects and negatively regulated the NLRP3 complex, inflammatory parameters and neurogenesis in the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"While ILG inhibits NLRP3-activated ASC oligomerization, GL inhibits NLRP3- and AIM2-activated ASC oligomerization [ 23 ], suggesting that ILG inhibits the NLRP3 inflammasome activation at the level of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36344171
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"We showed that 1,2,4-TTB (1mM) markedly suppressed nigericin- or ATP induced NLRP3 inflammasome activation, thus decreased caspase-1 activation and IL-1beta secretion in immortalized murine bone marrow derived macrophages (iBMDMs) and in primary mouse microglia."
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"The ATP induced NLRP3 inflammasome activation requires activation of the P2X 7 receptor in combination with the pannexin-1 channel and decreases intracellular potassium levels [XREF_BIBR, XREF_BIBR]."
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"Thus, our results indicated that methyl gallate was a classical NLRP3 inhibitor.Consistent with the results from mouse BMDMs, methyl gallate significantly reduced ATP-induced robust inflammasome activation in cultured PBMCs isolated from healthy subjects and inhibit the pre-activated NLRP3 inflammasome in patients’ SFCs."
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"Our study is also the first to report that treatment of THP-1 cells with S. mitis can lead to inhibition of ATP induced activation of NLRP3 and Caspase-1."
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"In addition, DI promoted LPS + ATP-inhibited autophagy, while suppression of autophagy with 3-MA mitigated DI effects on the levels of IL-1β, cleaved GSDMD and NLRP3, indicating that DI played an anti-inflammatory role by inducing autophagy."
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"In summary, activated CD4+ CD45RO+ memory T-cells suppress ATP triggered NLRP3 inflammasome activation in monocytes by the inhibition of P2X7R mediated signaling."
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"Furthermore, ATP induced NLRP3 inflammasome activation is strongly inhibited when NLRP3 is ubiquitinated, or NLRP3 deubiquitination is blocked, which indicates that NLRP3 deubiquitination is an essential posttranslational protein modification for NLRP3 activation."
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"A study [123] found that glibenclamide combined with ATP-sensitive K channel could inhibit NLRP3."
36620089
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"It was demonstrated that CY-09 and ATP competitively bound to the Walker A of ATPase, thereby inhibiting the ATPase activity of NLRP3."
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"Glyburide, an ATP-sensitive potassium channel inhibitor, can suppress the NLRP3-dependent maturation of pro-caspase-1 and pro-IL-1 β [ 85 ]."
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"Disruption of glycolysis and decreased ATP production have been reported to activate the NLRP3 inflammasome, and the activation of NLRP3 has an important effect on the differentiation and function of innate immune cells, such as macrophages [XREF_BIBR, XREF_BIBR]."
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"In 2019, R. C. Coll proved that MCC950 directly interacts with the Walker B motif within the NLRP3 transcription region to block ATP hydrolysis and inhibit NLRP3 activation (Coll et al., 2019)."
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"Pretreatment with Ca -chelating agent BAPTA-AM prior to stimulation with LPS and ATP or exposing to mycobacterium abscessus attenuated activation of NLRP3 inflammasome in macrophages (Lee H. M. et al., 2012)."
35493086
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"To further determine the effect of CS on inhibiting ATP induced activation of NLRP3 inflammasome, we treated BMDMs with CS at either the priming or the activating step, respectively."
28415686
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"Jiang et al. found that the compound of CY-09 inhibits the assembly and activation of NLRP3 inflammasome by binding to the ATP sequence of NACHT domain to inhibit the ATPase activity of NLRP3."
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"Similarly, some studies have shown that resveratrol ( 8 ) also exerts its anti-inflammatory activity by inhibition of LPS/ATP-induced NLRP3 activation [ 119 , 120 ]."
32829014
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"To elucidate the regulatory relationship of NF-κB in LPS and ATP-stimulated macrophages, cells were treated with LPS in the presence or absence of DIP (12.5 μg/mL) or Bay11-7082 (inhibitors with abili[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"LPS/ATP-mediated NLRP3 activation reduced cell proliferation and recovery of wound healing in both BC cell lines."
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"IF analysis (Fig. 4b, f) also confirmed that LPS/ATP co-stimulation led to a significant increase of NLRP3 fluorescent spots in cells (P < 0.01), whereas intervention with PLD significantly reduced the formation and expression of NLRP3 fluorescent spots (P < 0.01); 5.0 μM PLD was more effective than 2.5 μM PLD (P < 0.05)."
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"Similarly, ATP induced NLRP3 inflammasome activation was also blocked by echinatin (XREF_SUPPLEMENTARY)."
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"We did not observe any significant decrease in ATP induced NLRP3 activation when monocytes were cotreated with UFAs."
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"Furthermore, in EAE, dendritic cells’ hydrolysis of extracellular ATP prevents the activation of the NLRP3 inflammasome."
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"The signals of LPS plus ATP stimulated NLRP3 inflammasome disrupt the balance of K +, Ca 2+, and MMP, which promote the generation of reactive oxygen species (ROS) [XREF_BIBR - XREF_BIBR]."
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"There was a significant difference between the LPS/ATP and Piog + Nrf2-siRNA + LPS/ATP groups, which confirmed that Piog partially inhibited the NLRP3 inflammasome through the Nrf2 pathway (Figure 4(e))."
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"On the other hand, ATP surprisingly blocked activation of the NLRP3 inflammasome in alternatively activated macrophages."
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"These results indicated that Dex exerts an anti-inflammatory effect by directly suppressing the activation of NLRP3 inflammasome induced by LPS + ATP in BV2 cells."
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"Importantly, we have previously demonstrated that MSC reduce the CVB3 induced ROS production in cardiomyocytes 18, whereas Oh et al. 20 recently illustrated that MSC decrease mitochondrial ROS and inhibit LPS- and ATP induced NLRP3 inflammasome activation in macrophages primarily by secreting STC-1."
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"Inhibition of ASM activity attenuates LPS and ATP induced NLRP3 inflammasome and TXNIP mRNA expression in J774A.1 cells and THP-1 macrophages."
| PMC
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"MCC950 is a small‐molecule NLRP3 inhibitor that specifically binds to the ATP hydrolysis or Walker B motif of NLRP3, thereby preventing NLRP3 activity and IL‐1β maturation and production (Coll et al., 2015, 2019)."
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"Inhibition of TXNIP attenuates LPS and ATP induced NLRP3 inflammasome activation in J774A.1 cells and THP-1 macrophages."
| PMC
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"Therefore, LPS–ATP was applied to CRC cells for the remaining analysis.LPS–ATP-induced NLRP3 activation decreased the proliferation of CRC cells."
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"Knockdown of TWIK2 significantly impaired the inhibitory effect of ML365 on ATP induced NLRP3 inflammasome activation."
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"Intraperitoneal injection of ATP exacerbated and Z1456467176 inhibited MSU crystal-induced activation of the NLRP3 inflammasome pathway (Figure 7C)."
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"Under physiological conditions, NLRP3 was ISGylated following LPS stimulation, whereas ATP and Nig stimulation decreased NLRP3 ISGylation in both mouse PMs and THP-1 cells (Figure 5C and Supplemental Figure 5B)."
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"In line with a role for pannexin-1 in intracellular uptake of bacterial products upstream of cryopyrin signaling, the pannexin-1 inhibitory peptide blocked the ATP-induced uptake of the fluorescent dy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The mechanism of inhibition of ATP-induced NLRP3 inflammasome by HCQ in THP-1 macrophages was shown to due to the inhibition of Ca -activated K channels, including the KCa3.1 (KCNN4) channel, and consequent inhibition of K efflux (Eugenia Schroeder et al., 2017)."
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"In contrast, Nomura and colleagues showed that it is the diminished levels of intracellular ATP, which activate NLRP3 inflammasome in human and murine macrophages ( Nomura et al., 2015 )."
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"Mechanistically, MCC950 interacts with Walker B motif of NACHT domain that is close to the ATP binding pocket, thereby blocking the hydrolysis of ATP and suppressing NLRP3 activation [247]."
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"Authors of this review discuss how CRP, AAT, and SLPI can inhibit the ATP-induced NLRP3 inflammasome-dependent maturation and release of IL-1β, and provide evidence that the control of IL-1β release may involve the activation of unconventional nicotinic acetylcholine receptors which inhibit the ionotropic function of the ATP receptor P2X7."
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"Besides the co-expression of P2X7 receptor with NLRP3 inflammasome in post-ischemic tubules, we further demonstrated that both extracellular ATP depletion and P2X7 receptor antagonist are improving ischemic AKI and inhibiting NLRP3 inflammasome."
33504771
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"Studies have shown that metformin blocks LPS-induced ATP-dependent synthesis of mtDNA (an NLRP3 ligand), without relying on the AMP-activated protein kinases AMPK or NF-kB."
37868953
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"In vitro addition of MSCs to lipopolysaccharide (LPS)- or ATP-activated macrophages inhibited the NLRP3 activation in this immune cell."
30703433
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"Mechanistically, MCC950 interacts directly with the Walker B motif within the NLRP3 NACHT structural domain, thereby blocking ATP hydrolysis (154) and inducing the transition of NLRP3 to an inactive conformation (155)."
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"Therefore, the decrease in ATP level could activate NLRP3, while the increase in AMP/ATP ratio could activate AMPK."
37925428
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"ATP reduction and rapid ROS increase and other diverse endogenous danger signals caused by ischemic injury of brain tissue could mediate the activation of the NLRP3 inflammasome in the pathophysiological process of ischemia stroke [10]."
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"Using glyburide, an inhibitor of K potassium channel activity and extracellular ATP-induced NLRP3 activation, they showed an improvement in wound closure and a reduction in ongoing inflammation at 10 days post-wounding."
38426101
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"We found that the induction of IL-1beta secretion by nigericin or ATP was increased in BMDMs from TKO mice and PP2 pretreated THP-1 cells, suggesting that SFKs may suppress nigericin- or ATP induced NLRP3 inflammasome activation."
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"Proteolysis of the NLRP3 protein was not observed with heat killed Pg and inhibition of ECs protein synthesis with cycloheximide did not abolish the NLRP3 protein degradation induced by Pg infection in ATP pre-treated cells."
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"The accompanying study by Coll et al. shows that MCC950 do not binds NEK7, but directly targets NLRP3 at a site within or close to the Walker B motif and blocks ATP hydrolysis, blocking NLRP3 activation XREF_BIBR."
31086329
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"SFN suppressed NLRP3 inflammasome activation induced by MSU crystals, adenosine triphosphate and nigericin but not by poly (dA : dT) in primary mouse macrophages, independent of the reactive oxygen species pathway."
29340626
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"Further studies demonstrated that 2APB can inhibit nigericin- and ATP-induced NLRP3 inflammasome signaling cascade independently of its effect on calcium flux (Katsnelson et al., 2015)."
35754962
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"Previous studies have shown that PM(2.5) can cause alterations in adenosine triphosphate (ATP), and an increase in extracellular ATP and a decrease in intracellular ATP can trigger the activation process of the NLRP3 inflammasome."
35064883
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"We confirmed previously reported observations that pre-treatment of LPS primed myeloid cells with 2-APB prior to stimulation by nigericin (or ATP) completely suppresses all indices of the activated NLRP3 signaling cascade."
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"Collectively, these results suggest that LPS and ATP stimulation impairs mitochondrial function and cytosolic mtDNA leakage contributes to NLRP3 inflammasome activation.Autophagy is a mechanism for ma[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Intracellular ATP Decrease Mediates NLRP3 Inflammasome Activation upon Nigericin and Crystal Stimulation."
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"Nevertheless, when compared with ω-6 PUFAs, ω-3 were more potent in inhibiting ATP-mediated NLRP3 inflammasome [158] ."
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"Collectively, these results indicate that compound E6 does not affect LPS-induced priming step at 0.5–2 μM, but specifically affects the activation process of the NLRP3 inflammasome.Although compound [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, miR-223-inhibitor reversed the inhibition of LPS and ATP induced NLRP3, caspase 1 and IL-1β expressions in hepatocytes.The effect of LPS and ATP as well as exosomes on LDH release in AML1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, in 2021, Hongxu Xian et al. [53] found that independent of AMPK or NF-κB pathways, metformin blocked LPS-induced ATP-dependent synthesis of the NLRP3 ligand mtDNA and ultimately affected interleukin (IL)-1β production, while metformin may also affect inflammasome non-dependent IL-6 secretion via JNK and p38-MAPK activation, thereby attenuating LPS and SARS-CoV-2-induced ARDS."
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"It has also been confirmed when the inhibition of NADPH oxidase, induced by ROS, inhibited NLRP3 activation in macrophages treated with ATP [XREF_BIBR]."
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"proposed that significant cell death was observed only when P2X7R and NLRP3 inflammasome were both inhibited by ATP and MCC950, a specific inhibitor of NLRP3 inflammasome, and further research into safety manipulation of NLRP3 inflammasome without enhancing significant dose dependent side effects is required."
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"The increase of NOS2 derived NOin macrophages primed with LPS for 12 h results in the suppression of the ATP induced NLRP3 inflammasome activation.34,35 To investigate the effect of NO on SESN2 levels, weFigure 1."
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"Pg + ATP downregulated NLRP3 , ASC , POP1 , but upregulated IL-1beta and CARD16 ."
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"Overexpression of clusterin using Ad-Clu decreased LPS/ATP-induced NLRP3 and IL-1β mRNA expression and IL-1β secretion (Fig. 6A, B)."
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"Next, we determined the effect of miR-146a-5p knockdown in the LPS and ATP induced NLRP3 inflammasome activation."
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"In addition, using ATP synthesis inhibitors, oligomycin and 2-deoxyglucose, it was observed that decreased ATP level induced NLRP3 activation and necrosis while increased ATP led to apoptosis."
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"The co-culture experiment also demonstrated that BMSCs have the potent ability to inhibit the LPS + ATP induced activation of the NLRP3 inflammasome in KCs, which exhibited decreased expression of NLP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In other words, the ERK1 inhibitor reversed the inhibitory effect of PGE2 on the LPS + ATP-induced activation of the NLRP3 inflammasome."
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"HO-1 has been also reported as an important inhibitor of Nlrp3 inflammasome that as we recently proposed orchestrates via innate immunity cells the ATP-mediated mobilization process [11]."
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"Overall, these findings indicate that YM3-PRF treatment effectively attenuates the LPS + ATP-induced NLRP3 inflammasome pathway by inhibiting NF-κB nuclear translocation."
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"Collectively, these data revealed that Ro5-4864 was a potent drug for the reduction of IL-1beta and IL-18 release through suppression of ATP induced NLRP3 inflammasome activation in the representative[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We found that pretreatment with PIC ameliorated mitochondrial damage, inhibited ROS production I/R-induced in macrophages, and improved cell viability, ATP production and GSH-Px activity, which inhibi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pg+ ATP downregulated NLRP3, ASC, POP1, but upregulated IL-1beta and CARD16."
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"In contrast, ATP stimulated IL-1beta production was completely suppressed in the same Asc -/- and Nlrp3 -/- Nlrc4 -/- BMDC preparations."
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"These results support that the impairment of microglial autophagy by Atg5-siRNA aggravated LPS/ATP-induced NLRP3 inflammasome activation.After identifying the effect of impaired autophagy on NLRP3 inf[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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