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ATP inhibits NLRP3. 37 / 37
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"Besides the co-expression of P2X7 receptor with NLRP3 inflammasome in post-ischemic tubules, we further demonstrated that both extracellular ATP depletion and P2X7 receptor antagonist are improving ischemic AKI and inhibiting NLRP3 inflammasome."
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"Next, we determined the effect of miR-146a-5p knockdown in the LPS and ATP induced NLRP3 inflammasome activation."
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"HO-1 has been also reported as an important inhibitor of Nlrp3 inflammasome that as we recently proposed orchestrates via innate immunity cells the ATP-mediated mobilization process [11]."
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"Pg+ ATP downregulated NLRP3, ASC, POP1, but upregulated IL-1beta and CARD16."
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"LPS/ATP-mediated NLRP3 activation reduced cell proliferation and recovery of wound healing in both BC cell lines."
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"Collectively, these data revealed that Ro5-4864 was a potent drug for the reduction of IL-1beta and IL-18 release through suppression of ATP induced NLRP3 inflammasome activation in the representative[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To further determine the effect of CS on inhibiting ATP induced activation of NLRP3 inflammasome, we treated BMDMs with CS at either the priming or the activating step, respectively."
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"Proteolysis of the NLRP3 protein was not observed with heat killed Pg and inhibition of ECs protein synthesis with cycloheximide did not abolish the NLRP3 protein degradation induced by Pg infection in ATP pre-treated cells."
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"Similarly, ATP induced NLRP3 inflammasome activation was also blocked by echinatin (XREF_SUPPLEMENTARY)."
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"Previous studies have shown that PM 2.5 can cause alterations in adenosine triphosphate (ATP), and an increase in extracellular ATP and a decrease in intracellular ATP can trigger the activation process of the NLRP3 inflammasome."
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"Disruption of glycolysis and decreased ATP production have been reported to activate the NLRP3 inflammasome, and the activation of NLRP3 has an important effect on the differentiation and function of innate immune cells, such as macrophages [XREF_BIBR, XREF_BIBR]."
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"The ATP induced NLRP3 inflammasome activation requires activation of the P2X 7 receptor in combination with the pannexin-1 channel and decreases intracellular potassium levels [XREF_BIBR, XREF_BIBR]."
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"ATP reduction and rapid ROS increase and other diverse endogenous danger signals caused by ischemic injury of brain tissue could mediate the activation of the NLRP3 inflammasome in the pathophysiological process of ischemia stroke [10]."
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"proposed that significant cell death was observed only when P2X7R and NLRP3 inflammasome were both inhibited by ATP and MCC950, a specific inhibitor of NLRP3 inflammasome, and further research into safety manipulation of NLRP3 inflammasome without enhancing significant dose dependent side effects is required."
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"In contrast, ATP stimulated IL-1beta production was completely suppressed in the same Asc -/- and Nlrp3 -/- Nlrc4 -/- BMDC preparations."
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"The signals of LPS plus ATP stimulated NLRP3 inflammasome disrupt the balance of K +, Ca 2+, and MMP, which promote the generation of reactive oxygen species (ROS) [XREF_BIBR - XREF_BIBR]."
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"Nevertheless, when compared with ω-6 PUFAs, ω-3 were more potent in inhibiting ATP-mediated NLRP3 inflammasome [158] ."
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"Inhibition of ASM activity attenuates LPS and ATP induced NLRP3 inflammasome and TXNIP mRNA expression in J774A.1 cells and THP-1 macrophages."
| PMC
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"In addition, using ATP synthesis inhibitors, oligomycin and 2-deoxyglucose, it was observed that decreased ATP level induced NLRP3 activation and necrosis while increased ATP led to apoptosis."
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"We found that the induction of IL-1beta secretion by nigericin or ATP was increased in BMDMs from TKO mice and PP2 pretreated THP-1 cells, suggesting that SFKs may suppress nigericin- or ATP induced NLRP3 inflammasome activation."
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"SFN suppressed NLRP3 inflammasome activation induced by MSU crystals, adenosine triphosphate and nigericin but not by poly (dA : dT) in primary mouse macrophages, independent of the reactive oxygen species pathway."
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"It has also been confirmed when the inhibition of NADPH oxidase, induced by ROS, inhibited NLRP3 activation in macrophages treated with ATP [XREF_BIBR]."
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"Both acute and chronic liver injury models were used: lipopolysaccharide (LPS)/adenosine-triphosphate (ATP) to induce in vivo NLRP3 activation, choline-deficient, L-amino acid-defined high-fat diet (CDAA-HFAT), and Western-type diet to induce fibrotic-non-alcoholic steatohepatitis (NASH)."
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"We did not observe any significant decrease in ATP induced NLRP3 activation when monocytes were cotreated with UFAs."
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"In summary, activated CD4+ CD45RO+ memory T-cells suppress ATP triggered NLRP3 inflammasome activation in monocytes by the inhibition of P2X7R mediated signaling."
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"We showed that 1,2,4-TTB (1mM) markedly suppressed nigericin- or ATP induced NLRP3 inflammasome activation, thus decreased caspase-1 activation and IL-1beta secretion in immortalized murine bone marrow derived macrophages (iBMDMs) and in primary mouse microglia."
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"Importantly, we have previously demonstrated that MSC reduce the CVB3 induced ROS production in cardiomyocytes 18, whereas Oh et al. 20 recently illustrated that MSC decrease mitochondrial ROS and inhibit LPS- and ATP induced NLRP3 inflammasome activation in macrophages primarily by secreting STC-1."
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"Pg + ATP downregulated NLRP3 , ASC , POP1 , but upregulated IL-1beta and CARD16 ."
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"Thus, our results indicated that methyl gallate was a classical NLRP3 inhibitor.Consistent with the results from mouse BMDMs, methyl gallate significantly reduced ATP-induced robust inflammasome activation in cultured PBMCs isolated from healthy subjects and inhibit the pre-activated NLRP3 inflammasome in patients’ SFCs."
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"Our study is also the first to report that treatment of THP-1 cells with S. mitis can lead to inhibition of ATP induced activation of NLRP3 and Caspase-1."
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"Inhibition of TXNIP attenuates LPS and ATP induced NLRP3 inflammasome activation in J774A.1 cells and THP-1 macrophages."
| PMC
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"Furthermore, ATP induced NLRP3 inflammasome activation is strongly inhibited when NLRP3 is ubiquitinated, or NLRP3 deubiquitination is blocked, which indicates that NLRP3 deubiquitination is an essential posttranslational protein modification for NLRP3 activation."
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"We confirmed previously reported observations that pre-treatment of LPS primed myeloid cells with 2-APB prior to stimulation by nigericin (or ATP) completely suppresses all indices of the activated NLRP3 signaling cascade."
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"Knockdown of TWIK2 significantly impaired the inhibitory effect of ML365 on ATP induced NLRP3 inflammasome activation."
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"The accompanying study by Coll et al. shows that MCC950 do not binds NEK7, but directly targets NLRP3 at a site within or close to the Walker B motif and blocks ATP hydrolysis, blocking NLRP3 activation XREF_BIBR."
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"Intracellular ATP Decrease Mediates NLRP3 Inflammasome Activation upon Nigericin and Crystal Stimulation."
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"Our present study demonstrated that KM inhibited LPS and ATP induced pyroptosis and the release of IL-1beta/18 in J774A.1 cells by inhibiting the activation of GSDMD and caspase-1 and the assembly of NLRP3 inflammasome."
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