IndraLab

Statements

USP15 activates DNA Damage. 5 / 5
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"Moreover, we demonstrated that ATM is essential for USP15 -mediated regulation of radiation-induced DNA damage and intestinal injury."
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"Whether USP15 also modulates MDMX stability, how the activity of USP15 is regulated, and whether DNA damage impacts USP15 activity toward MDM2 remain to be elucidated."
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"To further clarify the mechanism by which USP15 regulates radiation-induced intestinal DNA damage and injury, mass spectrometry was used to identify proteins to which USP15 potentially binds."
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"In summary, these data suggest that USP15 regulates radiation-induced DNA damage and intestinal injury in an ATM-dependent manner."
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"USP15 regulates radiation-induced DNA damage and intestinal injury through K48-linked deubiquitination and stabilisation of ATM."
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