IndraLab

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OTUB2 increases the amount of SP1. 2 / 2

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"OTUB2 upregulated the protein expression of SP1 by inhibiting its ubiquitination degradation, thereby promoting the transcriptional activity of GINS1 and subsequently enhancing the stemness feature of colon cancer."

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"Consequently, we hypothesized that OTUB2 enhanced the stability of SP1 protein expression by deubiquitinating it, thereby promoting the transcriptional activity of GINS1."

39210373

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IndraLab

Statements

OTUB2 increases the amount of SP1. 2 / 2

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