IndraLab

Statements

USP6 activates Carcinogenesis. 4 / 4
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"Mice allografts stably expressing USP6 and its vector demonstrate that USP6-mediated NF-κB upregulation promotes tumorigenesis and tumor vascularization (60)."
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"The upregulation of USP6 expression is considered to initiate osteoblastic tumorigenesis by triggering NF-kappa-B activation and contributing to the osteolytic and inflammatory processes typically obs[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP6 has also been reported to initiate tumorigenesis via inducing the production of matrix metalloproteinases followed by NF-kappa-B activation [ 8 ]."
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"The role of calcium with USP32 is undefined, but USP6 (97% sequence identity with USP32 as a chimeric fusion of USP32 and TBC1D3 ) induces tumorigenesis in a calcium-dependent manner through interaction with the ubiquitous calcium-binding protein calmodulin ."
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