IndraLab

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OTUD6B activates MYC. 3 / 3
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"From a cell biological point of view, the OTUD6B‐LIN28B nexus links proteolytic ubiquitylation to mRNA biogenesis and eventually directs MYC activity to the G1/S cell cycle transition, a previously unappreciated crosstalk (Hildebrandt et al, 2017)."
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"OTUD6B activates MYC via LIN28B ."
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"Depletion of OTUD6B significantly reduced MYC mRNA and protein levels in various MM cell lines to a similar extent irrespective of the nature of MYC aberrations present in the individual lines (Fig 5C; Dib et al, 2008; Quentmeier et al, 2019)."
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