The INDRA Database

sparser

"Crucially, Ser9 is essential for this function: GSK3β activation increased phosphorylation of wild-type OTUD3, but not an S9A mutant, while treatment with GSK3β inhibitors such as Tideglusib disrupted this axis."

41437362

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sparser

"Then, we further explored the functions of PLK1 in OTUD3 phosphorylation."

38351178

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sparser

"Identification of OTUD3 phosphorylation by PLK1 adds a new layer of complexity to regulation of this signaling pathway and highlights the importance of phosphorylation in regulation of DUBs (Fig. xref )."

38351178

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sparser

"Pretreatment with the PLK1-specific inhibitor, HMN-214 (3 μM, 6 h), significantly inhibited OTUD3 phosphorylation (Fig. xref and Supplementary Fig. xref )."

38351178

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sparser

"Furthermore, EX527 repressed SeV-induced MAVS aggregation and the downstream signaling events, including IRF3 dimer formation and the phosphorylation of TBK1 and IRF3, in Otud3 +/+ but not Otud3 −/− M[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

32679077

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"Additional experiments showed that PLK1 failed to phosphorylate OTUD3 with Ser-326A mutations (Fig. xref )."

38351178

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sparser

"In summary, phosphorylation of the OTUD3 protein enhances its ability to bind YY1, ultimately further maintaining YY1 protein stability."

38351178

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sparser

"We found that PLK1 mediates OTUD3 phosphorylation to enhance its binding abilities, resulting in YY1 stability."