IndraLab

Statements

Dioxygen inhibits NLRP3. 4 / 4
| 4
reach
"Furthermore, BHB decreased reactive oxygen species (ROS) generation, inhibited ROS-NLRP3 pathway in OGD/R treated cells, and suppressed ER stress induced NLRP3 inflammasome activation."
29662437
reach
"Geng et al (188) observed that a high concentration of oxygen can inhibit the activation of the NLRP3 inflammasome and the inflammatory response after traumatic brain injury in mice."
39930811
reach
"24 In vitro studies confirm its presence in retinal pigment epithelial (RPE)25 cells and retinal endothelial cells.26 Animal studies have shown GLP-1’s benefits in diabetic retinopathy,27 33 oxygen-induced retinopathy,34 and ischemia-reperfusion injury.35 36 Its anti-inflammatory37 39 effects involve suppression of the NOD-like receptor protein 3 (NLRP3) inflammasome.40 41 which is implicated in choroidal neovascularization (CNV) models, where inhibition reduces CNV size.42 44We hypothesized that GLP-1R agonist administration mitigates CNV in AMD by suppressing inflammation."
40332908
reach
"SIRT3 is localized in mitochondria and plays an important role in the regulation of glucose metabolism and reactive oxygen species.SIRT3 activator restores the biological function of LPS-treated macro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38000586