IndraLab

Statements

Dioxygen inhibits NLRP3. 3 / 3
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"Furthermore, BHB decreased reactive oxygen species (ROS) generation, inhibited ROS-NLRP3 pathway in OGD/R treated cells, and suppressed ER stress induced NLRP3 inflammasome activation."
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"In continuation with our previous findings, we have further evaluated the mechanistic role of ATN-161 in vitro and found that oxygen and glucose deprivation and reperfusion (OGD/R)-induced inflammation, oxidative stress, apoptosis, mitochondrial depolarization, and fibrosis attenuate tight junction integrity via induction of α5, NLRP3, p-FAK, and p-AKT signaling in mouse brain endothelial cells."
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"Methods : Vascular reactivity, reactive oxygen species (ROS) generation, calcium (Ca 2+) influx and caspase-1 and IL-1beta activation were determined in mesenteric resistance arteries from normoglicemic and streptozotocin induced diabetic C57BL/6 and NLRP3 knockout (Nlrp3 -/-) mice."
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