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USP10 activates cellular senescence. 3 / 3
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"The inhibition of Usp10 attenuates senescence in both the osteocyte cell line, MLO‐Y4, and the osteoblast cell line, MC3T3‐E1, by downregulation of p53 and p21, preventing bone loss in OVX mice."
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"Usp10 inhibition attenuated H 2 O 2 -induced senescence in MLO-Y4 cells, as indicated by p53 and p21 quantification, a senescence associated beta-galactosidase (SA-beta-gal) assay, and p53 localization visualization with a confocal microscope."
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"USP10 has been reported to promote cell proliferation of hepatocellular carcinoma via deubiquitinating and stabilizing YAP/TAZ [29]; USP10 suppresses the growth and invasive capacity of lung cancer cells by overexpressing PTEN [30]; USP10 modulates oncogene-induced senescence through deubiquitination and stabilization of p14ARF [31]; USP10 propels cell proliferation in colon cancer through deubiquitinating and stabilizing Musashi-2 [32]."
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