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USP25 activates Interferon. 9 / 9
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"In addition, Lin et al. found that USP25, a deubiquitinating enzyme similar to USP5, promotes IRF3 and NF-κB activation and subsequent type I interferon and proinflammatory cytokine production after viral infection by stabilizing TRAF3 and TRAF6 [82]."
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"However, our studies explain that USP25 negatively modulates RIG-I and MDA5-dependent type I IFN signaling."
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"In addition , USP25 deficiency inhibits transcriptional activity of interferon regulatory factor , thereby reducing type I interferon production ( 20 ) ."
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"USP25 restricts proinflammatory cytokine production and promotes type I IFN production upon LPS stimulation."
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"Among identified candidates were known regulators of IFN signaling such as Usp25 ( Lin et al., 2015 ), Usp15 ( Pauli et al., 2014 ), and DUBA, which displayed reduced expression in H1N1-infected cells[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Intraperitoneal injection of VSV in 4-wk-old USP21 -/- also induced a stronger IFN production compared with that in 4-wk-old WT mice (unpublished data)."
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"Some of the reported mechanisms include regulation of suppressor of cytokine signaling 3-Phosphorylated signal transducer and activator of transcription 3, Wnt pathway/β-catenin, and NF-κB and c-Jun-N-terminal kinase (JNK) signaling pathways.27, 28, 30 29 A recent report showed that USP25 inhibited Toll-like receptor 4 (TLR4)-triggered proinflammatory signaling and promoted type I interferon signaling through deubiquitination of tumor necrosis factor receptor–associated factor (TRAF)3."
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"Mutation of the catalytic residues results in significant loss of ability of USP25 mediated IFN inhibition."
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"For instance, USP25 negatively regulated sendai virus-induced type I IFN signaling, thereby enhancing virus replication [ 47 ]."
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