IndraLab

Statements

2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide inhibits CHUK. 6 / 6
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"Our observation that BAY61-3606 is an inhibitor of IKKalpha has relevance beyond the study of HCMV replication."
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"Using in vitro kinase assays we found that BAY61-3606 is a potent inhibitor of the cellular kinase IKKalpha."
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"We observed that BAY61-3606 is a potent inhibitor of SYK, GCK and IKKalpha, but not IKKbeta or LYN, a kinase functionally unrelated to IKKalpha (XREF_FIG)."
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"Furthermore, we observed that a series of drugs structurally related to BAY61-3606 that do not inhibit IKKalpha had no effect on AD169 replication (XREF_FIG)."
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"Therefore, we confirm that BAY61-3606 is an inhibitor of IKKalpha and provide quantitative analysis of IKKalpha kinase inhibition by BAY61-3606."
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"Inhibition of IKKalpha by BAY61-3606 Reveals IKKalpha Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells."
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