IndraLab

Statements

OTUD7B inhibits RIPK1. 4 / 5
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"In addition, Cezanne blocked NF-κB pathway by targeting RIP1 for deubiquitination in epithelial and endothelial cells [ 20 ]."
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"However, combined pharmacological inhibition of RIPK1 activity (Nec1s) and apoptosis (zVAD-FMK) completely rescued survival of OTUD7b-deficient BMDC in vitro and in vivo indicating that OTUD7b inhibits RIPK1-independent and to a lesser extent RIPK1-dependent DC apoptosis [43]."
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"NF-kappaB Suppression by the Deubiquitinating Enzyme Cezanne|Our study provides several lines of evidence to suggest that Cezanne suppresses TNFR signaling to NF-κB by targeting RIP1 for deubiquitination."
18178551
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"It indicated that SFN modulated the expression of Cezanne to induce K63-mediated sequential deubiquitination and K48-mediated proteasomal degradation of TRAF6 and RIP1, eventually inhibiting the NF-κB[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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