IndraLab

Statements

OTUB1 inhibits DNA-templated transcription. 4 / 4
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"Mechanistically, OTUB1 inhibited IFN-gamma-induced Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling by K48 deubiquitination and stabilization of the JAK2 inhibitor suppressor of cytokine signaling 1 (SOCS1)."
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"When interacting with another ubiquitin protease and an E3 ubiquitin ligase, OTUB1 can inhibit cytokine gene transcription in the immune system [27,28] ."
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"The product of the OTUB1 gene is a member of the OTU superfamily of predicted cysteine proteases and inhibits cytokine gene transcription via its interaction with a ubiquitin protease and E3 ubiquitin ligase."
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"In rice, OTUB1 promotes the proteasomal degradation of a transcription factor OsSPL14 (SQUAMOSA promoter-binding protein-like), which is known to regulate grain yield."
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