IndraLab

Statements

CLU binds EIF3F. 17 / 21
| 7 10
sparser
"Therefore, these results suggest that eIF3f and CLU strongly interact with each other in the cytoplasm."
26988917
reach
"To identify the specific region responsible for the interaction between CLU and eIF3f, we generated four deletion constructs for CLU and eIF3f each and performed yeast two-hybrid assays."
26988917
reach
"Herein, we suggest a possible mechanism behind the eIF3f induced inhibition of tumor growth that involves the direct binding of eIF3f to CLU, which inhibits sCLU induced activation of Akt and ERK signaling."
26988917
sparser
"These results suggest that CLU can bind directly to eIF3f."
26988917
reach
"Therefore, because eIF3f interacts with CLU, the effect of eIF3f on cell proliferation requires the expression of CLU."
26988917
sparser
"To identify the specific region responsible for the interaction between CLU and eIF3f, we generated four deletion constructs for CLU and eIF3f each and performed yeast two-hybrid assays."
26988917
reach
"These results suggest that CLU can bind directly to eIF3f."
26988917
sparser
"EIF3f interacts with CLU in the cytoplasm."
26988917
sparser
"As shown in Figure xref , the region between amino acids 1 and 227 of CLU interacts directly with eIF3f, whereas the region between amino acids 1 and 169 of eIF3f interacts directly with CLU and was phosphorylated by CDK11p46 during apoptosis [ xref , xref ] (Figure xref )."
26988917
sparser
"The interaction between CLU and eIF3f was confirmed by growth assays and Δ-galactosidase assays using a yeast two-hybrid system."
26988917
sparser
"In addition, eIF3F can stabilize p53 and interact with CLU protein, a secretory heterodimeric glycoprotein thus leading to cancer cell proliferation in humans functioning as a CLU inhibitor xref ."
29167521
reach
"EIF3f interacts with CLU in the cytoplasm."
26988917
sparser
"These results suggest that eIF3f might interact with CLU protein to reduce the expression of sCLU in both intracellular and extracellular compartments by preventing structural changes."
26988917
reach
"The interaction between CLU and eIF3f was confirmed by growth assays and Delta-galactosidase assays using a yeast two-hybrid system."
26988917
sparser
"Therefore, because eIF3f interacts with CLU, the effect of eIF3f on cell proliferation requires the expression of CLU."
26988917
sparser
"Herein, we suggest a possible mechanism behind the eIF3f-induced inhibition of tumor growth that involves the direct binding of eIF3f to CLU, which inhibits sCLU-induced activation of Akt and ERK signaling."
26988917
reach
"To assess how eIF3f inhibits CLU activity, we generated several deletion constructs and analyzed the specific sites responsible for the binding between eIF3f and CLU."
26988917