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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

APBA2 activates HCN1. 2 / 2

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"Because HCN1 associates with amyloid-beta precursor protein (APP) and X11 and X11L in the brain, genetic deficiency of X11 and X11L may induce aberrant HCN1 distribution along with epilepsy."

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"While the localization of the channel likely affects its function, we can not rule out the possibility that X11 and X11L directly regulate HCN1 function as well."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...