IndraLab

Statements

USP19 inhibits MAP3K7. 2 / 2
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"USP19 negatively regulates the activation of TAK1-TAB1 dependent NF-κB signaling pathway by specifically removing TAK1 coupled Lys63 and Lys27 linked polyubiquitin chains, resulting in impaired TAK1 activity and destruction of the TAK1-TAB2/3 complex (207)."
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reach
"For example, USP19 inhibits Tnf and Il1b-triggered NF-κB activation by targeting TAK1 uncoupling of k27 and k63-linked polyubiquitin chains (35)."
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