IndraLab

Statements

OTUB1 translocates to the membrane. 4 / 4
| 1 3
sparser
"Otub1 is recruited to the membrane upon IL-15 signalling, and deubiquitinates the PH binding domain of AKT, thus reducing its ability to bind to PIP 3 and get activated."
38405398
sparser
"IL-15 mediates membrane recruitment of Otub1, which inhibits ubiquitin-dependent activation of AKT, a pivotal kinase for T cell activation and metabolism."
31182807
reach
"Otub1 is recruited to the membrane upon IL-15 signalling, and deubiquitinates the PH binding domain of AKT, thus reducing its ability to bind to PIP and get activated."
38405398
sparser
"For instance, OTUB1 was recruited to the membrane mediated by IL-15, which restrained the ubiquitin-dependent activation of AKT and thus inhibited the activation of CD8 + T and NK cells ( xref )."
40469292