IndraLab

Statements

Cholest-5-en-3-ol inhibits KCNMA1. 5 / 5
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"Cholesterol protection against alcohol induced BK channel inhibition and resulting cerebral artery constriction is unlikely to be mediated by a protein site that is specific for natural cholesterol."
27565113
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"Cholesterol inhibition of BK channel activity has been consistently reported in artificial bilayers of varied lipid composition : POPE : POPS (55/45 w/w), POPE : POPS (3:1 w/w), and 1,2-dioleoyl-3-phosphatidylethanolamine (DOPE) : sphingomyelin (SPM) (3:2 molar ratio), such inhibition being drastically reduced in pure POPE bilayers."
22584144
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"Cholesterol antagonism of slo1 channel activation by ethanol, however, has been attributed to a variety of factors."
25538625
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"Cholesterol reduced the activation energy of the BK channel by 50% for the open to closed transition."
7714888
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"Cholesterol recognition motif mutations reduce SLO induced B cell cytotoxicity and membrane binding."
31694896