IndraLab

Statements

SPATA2 inhibits CYLD. 3 / 5
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"By enhancing the deubiquinase activity of CYLD, SPATA2 also limits the NLRP3 activation and inflammatory responses by enhancing CYLD deubiquitinase activity ."
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"Together, these data indicate that both SPATA2 and CYLD, independently from each other, attenuate receptor complex ubiquitylation and thereby restrict pro-inflammatory gene expression and cell surviva[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The fact that KO of SPATA2 already prevents association of CYLD with the TNFR1 (XREF_FIG D) indicates that SPATA2L can not simply substitute for SPATA2, at least in the cellular systems tested."
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