IndraLab

Statements

TLR4 activates CYLD. 5 / 5
| 5
reach
"One the other side, TLR4 activates caspase-8 in a TNF-independent manner and promotes so the “inactivating” cleavage of the deubiquitinase Cyld (Legarda et al., 2016; Figure 4)."
31192209
reach
"Cleavage of CYLD induced by TLR4 stimulation was not affected in the Myd88 -/- BMDMs (XREF_FIG), but was abrogated in the Trif -/- BMDMs (XREF_FIG), indicating that CASPASE-8 activation was dependent on TRIF."
27264187
reach
"The LPS induced TLR-4 ligation recruits FADD and caspase-8 in a complex and initiates the cleavage of CYLD."
32381176
reach
"The LPS induced TLR-4 ligation recruits FADD and caspase-8 in a complex and initiates the cleavage of CYLD (Legarda et al., 2016) ."
| DOI
reach
"For instance, A20 and cylindromatosis (CYLD) induced by TLR4 signaling suppress downstream signaling by cleaving the K63-linked polyubiquitin chain of TRAF6 as deubiquitinating enzymes [11,12,13]."
38667302