IndraLab

Statements

TLR4 activates CYLD. 5 / 5
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"Cleavage of CYLD induced by TLR4 stimulation was not affected in the Myd88 -/- BMDMs (XREF_FIG), but was abrogated in the Trif -/- BMDMs (XREF_FIG), indicating that CASPASE-8 activation was dependent on TRIF."
27264187
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"The LPS induced TLR-4 ligation recruits FADD and caspase-8 in a complex and initiates the cleavage of CYLD."
32381176
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"The LPS induced TLR-4 ligation recruits FADD and caspase-8 in a complex and initiates the cleavage of CYLD (Legarda et al., 2016) ."
| DOI
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"One the other side, TLR4 activates caspase-8 in a TNF-independent manner and promotes so the “inactivating” cleavage of the deubiquitinase Cyld (Legarda et al., 2016; Figure 4)."
31192209
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"The Pseudomonas aeruginosa HSP90 like protein HtpG regulates IL-8 expression through NF-kappaB and p38 MAPK and CYLD signaling triggered by TLR4 and CD91."
32896641