IndraLab

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USP5 activates FOXM1. 3 / 4
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"For example, Li et al. showed that USP5 inhibition could significantly slow the growth of pancreatic tumors and promote the tumorigenesis and progression of pancreatic cancer by stabilizing the FoxM1 protein, which provided a basis for USP5 as a potential target for PDAC treatment [84]."

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"In addition, USP5 expression is significantly upregulated within pancreatic cancer cell lines, enhancing FoxM1 stability and extending its half-life."

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"To investigate whether USP5 prolonged the half-life of FoxM1, we transfected PANC-1 cells with USP5 and measured FoxM1 expression level in the presence of the translational inhibitor CHX."