IndraLab

Statements

COPS6 inhibits FOXO4. 9 / 9
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"We have shown that CSN6 decreases FOXO4 stability."
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"As CSN6 mitigates the expression level of FOXO4 , we showed that CSN6 overexpression leads to increased gene expression of Glut1 ( Figure 5F , Figure S15A , Supporting Information ) ."
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"Since MDM2 was shown as an E3 ligase for FOXO4 proteins, 33 , 34 we examined whether MDM2 is involved in CSN6‐mediated FOXO4 degradation."
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"We further investigate how CSN6 downregulates FOXO4 ."
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"2.1 EGF Signal and CSN6/COP1 Enhance Ubiquitin-Mediated Degradation of FOXO4."
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"39 Our studies show that constitutively active mutant FOXO4A3, 41 an PKB/Akt phosphorylation mutant of FOXO4, is still sensitive to CSN6/COP1‐mediated degradation, suggesting that CSN6/COP1‐mediated FOXO4 degradation is not similar to the action mode of Skp2 or MDM2."
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"] Our data indicates that CSN6 enhances ubiquitin-mediated degradation of FOXO4 through K48 link ubiquitination , thereby downregulating FOXO4 ."
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"Importantly, EGF‐mediated down regulation of FOXO4 can be reversed by the knockdown of CSN6 (Figure 1D), suggesting the involvement of CSN6 during this process."
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"We further investigate how CSN6 downregulates FOXO4."
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