IndraLab

Statements

USP48 binds HEG1. 6 / 6
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"We identify USP48 as a novel upstream regulator of HEG1: USP48 binds directly to HEG1 and selectively removes K48-linked polyubiquitin chains, thereby abrogating proteasomal degradation and reinforcing HEG1’s oncogenic activity."
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"HEG1 interacts with USP48 and is positively regulated by USP48 in STAD."
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"We found that USP48 binds to HEG1, and the level of HEG1 protein decreases after USP48 is knocked down."
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"Overall, our findings propose a novel USP48–HEG1 axis in gastric cancer and provide a foundation for future investigations into the biological functions of HEG1 stabilization and the potential of USP48 as a therapeutic target."
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"To investigate the functional interaction between USP48 and HEG1 in the progression of gastric cancer, we first established USP48 knockdown models in SGC-7901 and AGS cells."
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"Furthermore, our study demonstrates that HEG1 physically interacts with USP48 and is positively regulated by this deubiquitinase."
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