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Smo-1 activates ATXN3. 1 / 1
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"On the other hand, our findings that SUMO overexpression did not increase LC3 puncta formation and instead enhanced the co-localization of ataxin-3 with LC3 raise a possibility that SUMO-1 overexpression increases SUMOylation of certain components involved in substrate (cargo) recruitment for autophagy, which in turn accelerates the turnover of substrates."