IndraLab

Statements

USP15 activates Cicatrix, Hypertrophic. 8 / 8
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"USP15 Promotes the Proliferation, Migration, and Invasion of Hypertrophic Scar-Derived Fibroblasts."
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"The Cell Counting Kit-8, scratch, and invasion assays showed that USP15 knockdown significantly inhibited the proliferation, migration, and invasion of the hypertrophic scar–derived fibroblasts, and USP15 overexpression showed the opposite trends."
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"In conclusion, USP15 enhances the proliferation, migration, and collagen deposition of hypertrophic scar–derived fibroblasts by deubiquitinating TβRI in vitro."
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"Conclusion:. USP15 enhances the proliferation, migration, invasion, and collagen deposition of hypertrophic scar-derived fibroblasts by deubiquitinating TbetaRI in vitro."
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"Cell Counting Kit-8 assays showed that USP15 knockdown significantly inhibited the proliferation of hypertrophic scar–derived fibroblasts (62.06 ± 10.46 percent; p < 0.05), whereas USP15 overexpression significantly promoted the proliferation of hypertrophic scar–derived fibroblasts (147.97 ± 10.49 percent; p < 0.05."
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"(Center, right) The migration of hypertrophic scar fibroblasts in blank, vector, and USP15 groups was detected by scratch assays (*p < 0.05), http://links.lww.com/PRS/E645.] Scratch assays showed that USP15 knockdown significantly inhibited the migration of hypertrophic scar–derived fibroblasts (79.25 ± 0.71 percent; p < 0.05), whereas USP15 overexpression significantly promoted the migration of hypertrophic scar–derived fibroblasts (163.84 ± 0.21 percent; p < 0.05) (see Figure, Supplemental Digital Content 2, http://links.lww.com/PRS/E645)."
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"Matrigel invasion assays showed that USP15 knockdown significantly inhibited the invasion of hypertrophic scar–derived fibroblasts (0.37 ± 0.03-fold; p < 0.05), whereas USP15 overexpression significantly promoted the invasion of hypertrophic scar–derived fibroblasts (2.17 ± 0.11-fold; p < 0.05)."
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"(Right) The invasion of hypertrophic scar fibroblasts in blank, vector, and USP15 groups was detected by Matrigel invasion assays (*p < 0.05), http://links.lww.com/PRS/E646.] These results suggest that USP15 promotes the proliferation, migration, and invasion of hypertrophic scar–derived fibroblasts."
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