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OTUB1 activates Neoplasm Invasiveness. 59 / 59
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"By forming a protein complex, OTUB1 stabilizes active RhoA and promotes tumorigenesis and prostate cancer cell invasion."
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"In vitro studies have demonstrated that OTUB1 promotes prostate cancer invasion via RhoA activation."
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"They found that OTUB1 promotes the invasion and tumorigenesis of prostate cancer in vitro and in vivo by promoting Rho-A activation."
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"OTUB1 contributes to gastric cancer development by enhancing tumor invasiveness."
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"For example, OTUB1 can promote the progression, metastasis and invasion of gastric cancer (GC), prostate cancer and colon cancer (Zhou et al., 2014; Iglesias-Gato et al., 2015; Weng et al., 2016; Zhou et al., 2018)."
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"OTUB1 overexpression significantly accelerated HCC cell proliferation and invasion as RACK1 did; OTUB1 overexpression lost stimulation upon the RACK1-deficient HCC cells."
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"In prostate cancer, OTUB1 was reported to promote cell proliferation and invasion (38, 39)."
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"Similarly, the migration and invasion ability of OSCC cells were significantly suppressed by OTUB1 knockdown but simultaneously recover after RACK1 overexpression ( Fig. 10 b and c)."
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"OTUB1 promotes cancer cell invasion and tumorigenesis in various human cancers XREF_BIBR - XREF_BIBR, while the role of OTUB2 in cancer progression remains unknown."
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"We also find that OTUB1 promotes the growth and invasion of endometriosis cells."
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"Erratum : OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo."
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"Furthermore, our previous studies verified that OTUB1 and DUB1 promote gastric cancer cell progression and invasion by positively regulating Hippo signaling [22, 33]."
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"Currently, the only deubiquitinating enzyme of HSF1 reported is OTUB1, which promotes the proliferation and invasion of endometrial cells by promoting the protein stability of HSF1 through its deubiquitination [41], and they are colocalized in both the cytoplasm and nucleus."
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"OTUB1 promotes tumor invasion and predicts a poor prognosis in gastric adenocarcinoma."
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"XREF_BIBR, XREF_BIBR In addition, OTUB1 promotes tumourigenesis and cell invasion in prostate cancer."
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"OTUB1 was reported to promote prostate cancer cell proliferation and invasion (38, 39), which we further confirmed in this study with cell counting, CCK-8, and colony-formation assay in three different cell lines (Figs."
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"OTUB1 promote the migration and invasion of CRC cells in vitro by altering EMT markers."
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"OTUB1 has been proposed to promote the progression of myeloma (24), colorectal (9), prostate cancer (10), ovarian cancer (28), gastric cancer (12), HCC (12), and glioma (15) by facilitating tumor invasiveness."
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"The trans-well assay showed that the increased invasion capacity caused by OTUB1 overexpression could be recovered by YAP knockdown in MKN28 cells (Supplementary Fig. 2G)."
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"The results showed that OTUB1 overexpression enhanced the migration and invasion ability of both cells (Figures 5A and 5B)."
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"OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo."
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"These results demonstrated that OTUB1 might promote OSCC progression by enhancing the ability of cell proliferation, invasion, and migration.We found that OTUB1 affected the function of OSCC cells, an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTUB1 mediates prostate cancer cell invasion through RhoA activation and promotes tumorigenesis in vivo."
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"MicroRNA-542-3p represses OTUB1 expression to inhibit migration and invasion of esophageal cancer cells."
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"Finally, cell migration and invasion inhibition induced by miR-542-3p overexpression was partially attenuated by co-transfection of recombinant OTUB1 in KYSE150 cells."
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"In this study, OTUB1 enhanced the proliferation, migration, and invasion of endometriosis cells."
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"OTUB1 promotes the invasion of glioma cells, and inhibits CNS autoimmune [35, 36]."
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"To determine whether OTUB1‐isoform2 promotes ovarian cancer cell invasion and migration, we performed the wound healing and Transwell assays."
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"Ectopic expression of miR-542-3p which inhibits OTUB1 expression, attenuates proliferation, migration, and invasion while promoting apoptosis in colorectal cancer cells (Yuan et al., 2017)."
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"Diego Iglesias-Gato et al. found that OTUB1 promotes the invasion and tumorigenesis of prostate cancer in vitro and in vivo by mediating Rho-A and P53 [ 47 ]."
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"OTUB1 promotes the migration and invasion of CRC cell lines."
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"The results showed that knockdown of OTUB1 significantly suppressed the migration and invasion of SW620 cells."
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"In vitro experiments also suggested that OTUB1‐isoform2 promoted ovarian tumour cell proliferation and invasion."
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"Cell migration and invasion exhibited a similar pattern and were also promoted by overexpression of OTUB1 (Figure 5D)."
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"In the wound-healing and trans-well assays, YAP over-expression could also recover the cell migration and invasion speed, which was reduced by OTUB1 depletion in MKN28 cells (Fig. 4M, P)."
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"Moreover, OTUB1 knockdown effectively inhibited the invasion and migration of GBM cells, and the opposite phenomenon occurred with overexpression."
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"While prior to Yersinia infection, wild-type OTUB1 catalyzes the deubiquitination of active-form RhoA to stabilize the protein, and then enhances the cellular susceptibility to invasion."
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"The trans-well assay showed that the impaired invasion capacity caused by OTUB1 depletion could be partially recovered by YAP-S5A over-expression in MKN28 cells (Supplementary Fig. 3G)."
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"Furthermore, OTUB1 expression was upregulated and promoted cell invasion in hepatocellular carcinoma 14."
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"Together, our findings demonstrate that OTUB1 promotes the migration, invasion, and metastasis of CRC cells in vitro and in vivo and acts as a potential metastasis marker and prognostic factor in CRC."
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"Knockdown of OTUB1 suppressed cell proliferation , migration and invasion of RCC ."
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"While overexpression of WT OTUB1 leads to increased cell invasion, the expression of the OTUB1-C91S variant mimics the effects of OTUB1 siRNA knockdown, leading to reduced cell invasion."
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"Among these DUBs, OTUB1, and USP10 significantly enhanced cell proliferation and invasion (Figure 2A,B, Figure S2A)."
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"These results strongly confirmed that OTUB1 facilitates cell proliferation and inhibiting apoptosis.Moreover, OTUB1 overexpression enhanced the migration and invasion viability of U87 and U251 cells (Figures 3F and G; Figures S3F and G)."
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"We confirmed that OTUB1 overexpression led to a significant augmentation in both cell proliferation and invasion (Figure S3B,C)."
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"Knockdown of OTUB1 impaired the malignance of OSCC cells - suppressed cell proliferation , invasion , migration , and xenografted tumor growth ."
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"Notably, YAP1 depletion rescued the cell proliferation and invasion that were induced by OTUB1 overexpression (Figure 4F,G).3."
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"Functionally, OTUB1 promotes cell invasion in vitro through SNAIL."
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"The present study demonstrated that OTUB1 induced G1 to S phase transition, suppressed apoptosis, and promoted cell proliferation and invasion in vitro."
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"In vitro study showed OTUB1 promotes gastric cancer cell migration and invasion."
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"In vitro wound healing and transwell assays showed that OTUB1 overexpression promoted tumor cell migration and invasion in gastric cancer cells."
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"As a result, OTUB1 promotes gastric cancer cell proliferation, migration, and invasion as well as stemness through YAP1."
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"The authors showed OTUB1 inhibits ferroptosis in gastric cancer and promotes cell proliferation as well as migration and invasion."
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"These can be characterized by certain marker proteins, likely contributing to OTUB1 overexpression promoting GBM proliferation and invasion."
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"Recent research indicates that ETS1, OTUB1 and PTP4A1 could promote OSCC proliferation, invasion, and metastasis (7–9)."
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"Despite a recent report that OTUB1 stabilizes MDMX and induces apoptosis 46, OTUB1 stabilizes proteins linked to cancer progression such as RAS and FOXM1 via deubiquitination and promotes tumor growth and invasion 34,47."
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"Moreover, the knockdown of RACK1 reversed the overexpression of OTUB1-induced migration and invasion of HCC cells (Fig. 7b, d, g)."
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"Increasing OTUB1 expression might significantly restrain the extent and outcome of inflammatory damage.These studies have proved that OTUB1 promotes the proliferation and invasion of various cancers v[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A growing body of literature demonstrates that the DUB Otubain 1 (OTUB1) regulates many cancer associated signaling pathways including MAPK, ERa, epithelial-mesenchymal transition (EMT), RHOa, mTORC1, FOXM1 and P53 to promote tumor cell survival, proliferation, invasiveness and therapeutic resistance."
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