IndraLab

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OTUB1 activates Neoplasm Invasiveness. 23 / 23
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"OTUB1 promotes cancer cell invasion and tumorigenesis in various human cancers XREF_BIBR - XREF_BIBR, while the role of OTUB2 in cancer progression remains unknown."
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"Erratum : OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo."
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"OTUB1 promotes tumor invasion and predicts a poor prognosis in gastric adenocarcinoma."
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"OTUB1 promotes the migration and invasion of CRC cell lines."
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"In vitro wound healing and transwell assays showed that OTUB1 overexpression promoted tumor cell migration and invasion in gastric cancer cells."
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"Together, our findings demonstrate that OTUB1 promotes the migration, invasion, and metastasis of CRC cells in vitro and in vivo and acts as a potential metastasis marker and prognostic factor in CRC."
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"OTUB1 mediates prostate cancer cell invasion through RhoA activation and promotes tumorigenesis in vivo."
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"A growing body of literature demonstrates that the DUB Otubain 1 (OTUB1) regulates many cancer associated signaling pathways including MAPK, ERa, epithelial-mesenchymal transition (EMT), RHOa, mTORC1, FOXM1 and P53 to promote tumor cell survival, proliferation, invasiveness and therapeutic resistance."
30400005
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"MicroRNA-542-3p represses OTUB1 expression to inhibit migration and invasion of esophageal cancer cells."
31939620
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"The results showed that OTUB1 overexpression enhanced the migration and invasion ability of both cells (Figures 5A and 5B)."
36339263
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"While overexpression of WT OTUB1 leads to increased cell invasion, the expression of the OTUB1-C91S variant mimics the effects of OTUB1 siRNA knockdown, leading to reduced cell invasion."
25623341
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"Knockdown of OTUB1 suppressed cell proliferation , migration and invasion of RCC ."
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"We also find that OTUB1 promotes the growth and invasion of endometriosis cells."
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"In vitro experiments also suggested that OTUB1‐isoform2 promoted ovarian tumour cell proliferation and invasion."
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"To determine whether OTUB1‐isoform2 promotes ovarian cancer cell invasion and migration, we performed the wound healing and Transwell assays."
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"XREF_BIBR, XREF_BIBR In addition, OTUB1 promotes tumourigenesis and cell invasion in prostate cancer."
26148240
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"Finally, cell migration and invasion inhibition induced by miR-542-3p overexpression was partially attenuated by co-transfection of recombinant OTUB1 in KYSE150 cells."
31939620
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"In this study, OTUB1 enhanced the proliferation, migration, and invasion of endometriosis cells."
36339263
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"OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo."
25623341
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"By forming a protein complex, OTUB1 stabilizes active RhoA and promotes tumorigenesis and prostate cancer cell invasion."
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"While prior to Yersinia infection, wild-type OTUB1 catalyzes the deubiquitination of active-form RhoA to stabilize the protein, and then enhances the cellular susceptibility to invasion."
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"OTUB1 contributes to gastric cancer development by enhancing tumor invasiveness."
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"The results showed that knockdown of OTUB1 significantly suppressed the migration and invasion of SW620 cells."
25431208