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Resveratrol inhibits RELA. 16 / 48
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"Furthermore, resveratrol also inhibited the appearance of subunit p65 in the nucleus [XREF_BIBR]."
27834913
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"The activation of SIRT1 by resveratrol, leading to the inhibition of phospho-p38 MAPK as well as the reduced NF-kappaB p65 activity [XREF_BIBR]."
| PMC
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"The intervention of RA-FLSs with resveratrol significantly increases the expression of Nrf2 and HO-1, reduces the production of ROS and MDA and activation of nuclear factor kappa-B (NF-κB) p65, inhibits the proliferation and migration of RA-FLSs, and promotes its apoptosis (114, 115)."
36845127
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"To our knowledge, this study is the first to reveal that resveratrol targeting protein NQO2 plays a mediating role in resveratrol induced changes of NF-kappaB p65, which may contribute to the anti-CaP activities elicited by resveratrol."
19661309
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"Treatment of LPS-stimulated RAW264.7 cells with resveratrol-enriched rice seed extracts (DJ526_0 and DJ526_5) significantly decreased the production of nitric oxide (NO) and the inflammatory mediator prostaglandin E2 (PGE 2 ), downregulated proinflammatory gene expression, and inhibited nuclear factor kappa B (NF-κB) p65, p38 mitogen-activated protein kinase, and extracellular signal-regulated kinase 1/2 (ERK 1/2) phosphorylation."
37446559
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"AGEs+LPS treatment upregulated p-IKBα/IKBα and NF-κB p-p65/NF-κB p65 expression ratio in osteocytes and this effect was reversed by the treatment of ferrostatin-1 or resveratrol (Figure 6C,D; Supplementary Materials, Figure S3)."
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"Inversely, resveratrol dose-dependently decreased LPS-induced NF-κB p65, IL-6, and Iκ-Bα release by BV2 microglial cells (P < 0.001, Supplementary Fig 3A-C)."
39967065
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"In a premature senescence model using bone marrow mesenchymal stem cells, it was proved that resveratrol inhibits the progression of premature senescence via RELA/SIRT1 ( He et al., 2022 )."
37116286
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"Resveratrol can reduce production of the pro-apoptotic proteins p65 and Bax and of cleaved caspase-3, and it promotes the expression of the anti-apoptotic protein Bcl-2 ( Zhou et al., 2018 )."
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"To confirm that resveratrol suppresses nuclear retention of p65, we tested the intracellular location of NF-κB in RPMI 8226 cells using a fluorescence-based antibody assay."
16490592
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"The results showed that resveratrol, the activator of SIRT1, inhibited the binding of NF-kappaB p65 to the MMP-13 promoter, and the situation was the opposite after being treated with the inhibitor of SIRT1."
28473882
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"Resveratrol reduced the transcriptional activity of p65, but neither affected the DNA binding activity of NF-kappaB nor blocked the nuclear translocation of p65."
24020126
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"Recently, Lee et al. indicated that resveratrol inhibits the activation of NF-κB (p65) by TNF-α or PMA and reduces ATP-induced mucin secretion from cultured primary rat tracheal surface epithelial (RT[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22587816
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"These data confirmed the potential relationship to decreasing the expression of phosphorylated Akt-mediated suppression of NF-κB (p65) by resveratrol ( Fig. 7 D and E)."
30031063
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"Finally, we investigated whether resveratrol derivatives (AC, AF, and PD) inhibited TNF-α-induced NF-κB (p65) activation."
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"Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1)."
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