IndraLab

Statements

BTRC binds USP47. 28 / 33
7 | 8 13
biogrid
No evidence text available
25900982
sparser
"The interaction of USP47 and β-TrCP is regulated by ERAP1 xref , suggesting that each has a fine-tuned regulatory mechanism."
37740002
reach
"However, USP47 can both interact with and deubiquitinate β-TrCP."
37740002
reach
"The interaction of USP47 and β-TrCP is regulated by ERAP1 , suggesting that each has a fine-tuned regulatory mechanism."
37740002
biogrid
No evidence text available
28514442
reach
"Interaction between USP47 and β-TrCP, a subunit of the SCF β-TrCP E3 ubiquitin ligase complex, is involved in a number of signaling pathways [164,165,166]."
36497313
biogrid
No evidence text available
19966869
reach
"Moreover, Peschiaroli et al. revealed that BTRC specifically binds to USP47 to regulate cell survival [40]."
35509185
reach
"The study by Shi et al. (2015) investigating USP47 and β-TrCP interactions found that, unlike the typical β-TrCP binding site (DSGxxS), USP47 presents a novel recognition motif (DEGxxxE), in which the glutamic acid could mimic a phosphoserine."
34604226
biogrid
No evidence text available
25900982
sparser
"Therefore, FAM83H and SCRIB stabilize β-catenin protein by protecting it from proteasomal degradation via interaction with β-TrCP and USP47."
32564009
sparser
"The study by xref investigating USP47 and β-TrCP interactions found that, unlike the typical β-TrCP binding site (DSGxxS), USP47 presents a novel recognition motif (DEGxxxE), in which the glutamic acid could mimic a phosphoserine."
34604226
sparser
"Therefore, these findings suggest that both FAM83H and SCRIB stabilize β-catenin protein by inhibiting its proteasomal degradation via interaction with β-TrCP and USP47."
32564009
reach
"Moreover, endoplasmic reticulum aminopeptidase 1, a key regulator of innate and adaptive anti-tumor immune responses, was found to interact with USP47 and thus interfered with the interaction of USP47 and β-TrCP, leading to ubiquitination degradation of β-TrCP (Bufalieri et al., 2019)."
34604226
reach
"Another study showed that USP47 bound to β-TrCP and mediated its deubiquitination to stabilize its expression (Bufalieri et al., 2019)."
34604226
reach
"For example, USP47 could bind to β-TrCP through its unique “DEGICLE” motif (Shi et al., 2015)."
34604226
sparser
"Interaction between USP47 and β-TrCP, a subunit of the SCF β-TrCP E3 ubiquitin ligase complex, is involved in a number of signaling pathways [ xref , xref , xref ]."
36497313
sparser
"At the post-translational level, studies have shown that USP47 interacts with β-TrCP proteins in the E3 ubiquitin ligase complex SCF."
34604226
sparser
"However, later work found that β-TrCP could interact with USP47 through a novel motif “DEGxxxE” in HEK293T cells, and β-TrCP promotes the ubiquitination and degradation of USP47-inactivating mutants rather than wild-type USP47 due to its own ubiquitination properties, possibly explaining the controversial results presented in different studies ( xref )."
34604226
sparser
"Moreover, Peschiaroli et al. revealed that BTRC specifically binds to USP47 to regulate cell survival [ xref ]."
35509185
sparser
"Moreover, endoplasmic reticulum aminopeptidase 1, a key regulator of innate and adaptive anti-tumor immune responses, was found to interact with USP47 and thus interfered with the interaction of USP47 and β-TrCP, leading to ubiquitination degradation of β-TrCP ( xref )."
34604226
biogrid
No evidence text available
19615732
sparser
"Another study showed that USP47 bound to β-TrCP and mediated its deubiquitination to stabilize its expression ( xref )."
34604226
sparser
"For example, USP47 could bind to β-TrCP through its unique “ DEG ICL E ” motif ( xref )."
34604226
sparser
"Interestingly, β-TrCP directly binds to the USP47 motif at DSGXXXS and regulates USP47 ubiquitination [ xref ]."
37686524
sparser
"We found that both β-Trcp1 and β-Trcp2 bind specifically to USP47, and point mutations in the β-Trcp WD-repeat region completely abolished USP47 binding, indicating an E3-substrate-type interaction."
19966869
biogrid
No evidence text available
25332235
biogrid
No evidence text available
33961781