IndraLab

Statements

UCHL1 activates EGFR. 3 / 3
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"Together, these data highlight the importance of the UCHL1 mediated posttranslational mechanism of EGFR in cardiomyocytes in vitro and in vivo."
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"To further examine whether overexpression of UCHL1 in cardiomyocytes accelerates hypertrophy and dysfunction by influencing the stability of EGFR in vivo, we generated cardiomyocyte specific UCHL1 overexpressing and EGFR knockdown mice by injection with rAAV9-UCHL1 and rAAV9-siEGFR or their corresponding controls because EGFR full-knockout mice exhibit embryonic lethality."
32494592
reach
"Together, these results indicate that UCHL1 mediates cardiac hypertrophy and remodeling through deubiquitination and stabilization of EGFR in vivo."
32494592