IndraLab

Statements

UCHL1 activates EGFR. 4 / 4
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"To further examine whether overexpression of UCHL1 in cardiomyocytes accelerates hypertrophy and dysfunction by influencing the stability of EGFR in vivo, we generated cardiomyocyte specific UCHL1 overexpressing and EGFR knockdown mice by injection with rAAV9-UCHL1 and rAAV9-siEGFR or their corresponding controls because EGFR full-knockout mice exhibit embryonic lethality."
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"Together, these results indicate that UCHL1 mediates cardiac hypertrophy and remodeling through deubiquitination and stabilization of EGFR in vivo."
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"In TNBC, UCHL1 directly interacts with EGFR protein and suppresses EGFR degradation through the ubiquitin-proteasome pathway, leading to suppressed transcription of ESR1 [11]."
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"Together, these data highlight the importance of the UCHL1 mediated posttranslational mechanism of EGFR in cardiomyocytes in vitro and in vivo."
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