IndraLab

Statements

AGT activates SCN5A. 4 / 4
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"The results indicated that Ang II mediated SCN5A downregulation was dependent on the splicing factor RBM25 (XREF_FIG)."
21859973
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"Previous studies show that ANG II exposure led to downregulation of T-box5, a transcription factor critical for proper heart development, and Scn5a, the gene that encodes for cardiac sodium channel Na V 1.5, relative to control tissues."
26808388
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"The results indicated that AngII mediated SCN5A mRNA downregulation was dependent on PERK (XREF_FIG)."
24036084
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"While Ang II and hypoxia were sufficient to signal SCN5A abnormal splicing, there could be other heart failure associated factors that could contribute to SCN5A downregulation in vivo."
21859973