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SB 203580 inhibits JUN. 8 / 9
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"In some experiments, SP600125 (10 μmol/L; Sigma-Aldrich) and SB203580 (10 μmol/L; Sigma-Aldrich) were used to block c-jun NH 2 -terminal kinase (JNK) and mitogen-activated protein kinase (MAPK) p38, r[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23142380
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"SB203580 treatment alone, in the absence of db-cAMP, was not sufficient to induce the myelin associated proteins or down-regulate c-Jun (data not shown)."
22623660
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"p38 activity can be completely inhibited without effect on c-Jun phosphorylation, whereas 10 micrometer SB203580 strongly inhibits neuronal JNK2/3, stress induced c-Jun phosphorylation, induced c-Jun activity, and neuronal death in response to trophic withdrawal stress."
12040039
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"SB 203580 strongly inhibited the induction of c-fos and c-jun by anisomycin and UV radiation."
8805335
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"Moreover, the present study showed that IL-17A induced the nuclear translocation of c-Jun and c-Fos, which could be effectively inhibited by the JNK inhibitor SP600125 or the p38 inhibitor SB203580 (Fig. 6a)."
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"However, SB 203580 did not inhibit the induction of c-fos and c-jun in response to EGF; in fact, we consistently observed augmented c-fos and c-jun mRNA levels under these conditions."
8805335
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"LPS activation of nuclear factor-kappa B (NF-kappaB), activator protein-1 (AP-1) and p38 MAPK was also inhibited by SB 203580."
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"This is in accord with a previous study in which a specific inhibitor of p38 MAPK, SB203580, inhibited IL-2 production by suppressing the nuclear localization of c-Jun and activating transcription fac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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