IndraLab

Statements

SB 203580 inhibits JUN. 4 / 5
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"SB203580 treatment alone, in the absence of db-cAMP, was not sufficient to induce the myelin associated proteins or down-regulate c-Jun (data not shown)."
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"p38 activity can be completely inhibited without effect on c-Jun phosphorylation, whereas 10 micrometer SB203580 strongly inhibits neuronal JNK2/3, stress induced c-Jun phosphorylation, induced c-Jun activity, and neuronal death in response to trophic withdrawal stress."
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"LPS activation of nuclear factor-kappa B (NF-kappaB), activator protein-1 (AP-1) and p38 MAPK was also inhibited by SB 203580."
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"Moreover, the present study showed that IL-17A induced the nuclear translocation of c-Jun and c-Fos, which could be effectively inhibited by the JNK inhibitor SP600125 or the p38 inhibitor SB203580 (Fig. 6a)."
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