IndraLab

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CYLD activates inflammatory response. 18 / 18
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"These results suggest that PDE4B negatively regulates CYLD expression and mediates inflammation via the JNK pathway."
23575688
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"Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma : possible link to acquired resistance to anti-VEGF therapy."
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"Taken together, it is evident that PDE4B negatively regulates CYLD expression and mediates NTHi induced inflammation via specific activation of JNK2 but not JNK1 pathway."
23575688
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"Thus, we sought to determine whether increased cAMP does have an important role in inhibiting JNK2 activation, which in turn enhances CYLD expression and suppresses inflammation."
23575688
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"Vinpocetine suppresses Streptococcus pneumoniae-induced inflammation via inhibition of ERK1 by CYLD."
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"CYLD is upregulated in both COVID-19 and cardiomyopathy and was found to correlate with the activation of FGFR2, an important promoter of inflammation [51], and TXA2, a gene that is upregulated in platelets (See Appendix A, Figure A2A) [52]."
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"These data collectively suggested that Cyld deficiency leads to severe colonic inflammation and increased disruption of the epithelial barrier."
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"Knockdown of CYLD rescued compromised inflammatory response of macrophages induced by Notch blockade in I/R injury in vitro."
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"Inhibition of PDE4B markedly increased the expression of CYLD and subsequently suppressed bacteria induced inflammation in well established models of both lung and middle ear inflammation."
23575688
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"MiR-181b and miR-21 target cylindromatosis (CYLD) and phosphatase and tensin homolog (PTEN), respectively, and down-regulation of CYLD and PTEN leads to NF-kappaB activation, therefore also acting as a part of the epigenetic switch linking inflammation to cancer [XREF_BIBR]."
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"Indeed, it was found that deletion of CYLD -- which is required for RIPK activation downstream of TNF -- prevented inflammation caused by intestinal deletion of FADD, but not of NF-kB signaling 75."
22016059
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"Adoptive transfer of CYLD KO T cells into RAG KO mice that lack endogenous lymphocytes induced autoimmune symptoms and intestinal inflammation."
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"Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer."
22698400
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"NTHi induced CYLD expression, which in turn leads to negative regulation of NTHi induced NF-kappaB-dependent inflammation [XREF_BIBR]."
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"Adoptive transfer of Cyld -/- T cells induces autoimmune symptoms and colonic inflammation in recipient mice."
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"56 Wang and coworkers examined the role of deubiquitinase cylindromatosis (CYLD) in NTHi induced inflammation."
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"Consistently, the Cyld -/- T cells display a hyperresponsive phenotype and mediate the spontaneous development of intestinal inflammation in Cyld -/- mice."
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"By negatively regulating NF-kappaB activation, CYLD limits the inflammatory response during infections, thus minimizing tissue damage."
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