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"In mouse, one surprising finding is that NMDARs may be primed to open due to depolarization of the DSGC by acetylcholine receptor (AChR) activation in some stimulus conditions ( xref ). xref described a role for NMDARs in enhancing direction-selective signals: Local interactions between GABA receptors and voltage-dependent NMDARs lead to a balance between excitation and inhibition that aids DSGCs in maintaining directional tuning in noisy stimulus conditions."