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USP22 activates KDM1A. 10 / 12
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"USP22 could also mediate the stability of LSD1 via deubiquitination to promote cancer progression [ 46 , 47 ]."
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"These findings demonstrate that nuclear GSK3β- and USP22-mediated LSD1 stabilization promotes GSC stemness and glioblastoma tumorigenesis.More recently, DUB-mediated LSD1 stabilization has been suggested to contribute to breast cancer metastasis."
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"Our findings demonstrate that nuclear GSK3beta and USP22 mediated KDM1A stabilization is essential for glioblastoma tumorigenesis."
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"miR-140 inhibits osteosarcoma progression by impairing USP22 mediated LSD1 stabilization and promoting p21 expression."
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"In contrast, USP22 overexpression in 293T cells increased KDM1A stability (XREF_SUPPLEMENTARY)."
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"MiR-140 suppresses osteosarcoma progression by inhibiting USP22-mediated LSD1 stability, resulting in promoting ubiquitination of LSD1 and increasing p21 expression (105)."
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"Likewise, knockdown of USP22 inhibited GSC stemness (XREF_FIG and XREF_SUPPLEMENTARY), and exogenous KDM1A rescued the effect of USP22 depletion on GSC stemness (XREF_FIG and XREF_SUPPLEMENTARY)."
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"USP22 and GSK3β together in the nucleus mediate the stability of lysine (K)-specific demethylase 1A (KDM1A), a histone demethylase, and changes in histone H3K4 methylation level inhibit the transcript[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, microRNA 140 inhibits the USP22 mediated LSD1 stabilization, which halts the cell cycle (78)."
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"For instance, deubiquitinating enzyme USP10 promotes OS metastasis by stabilizing YAP1 [33], miR-140 inhibits OS progression by impairing USP22-mediated LSD1 stabilization [34]."
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