IndraLab

Statements

USP22 activates KDM1A. 4 / 6
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"Our findings demonstrate that nuclear GSK3beta and USP22 mediated KDM1A stabilization is essential for glioblastoma tumorigenesis."
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"miR-140 inhibits osteosarcoma progression by impairing USP22 mediated LSD1 stabilization and promoting p21 expression."
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"In contrast, USP22 overexpression in 293T cells increased KDM1A stability (XREF_SUPPLEMENTARY)."
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"Likewise, knockdown of USP22 inhibited GSC stemness (XREF_FIG and XREF_SUPPLEMENTARY), and exogenous KDM1A rescued the effect of USP22 depletion on GSC stemness (XREF_FIG and XREF_SUPPLEMENTARY)."
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