IndraLab

Statements

Poly I:C inhibits IFNB1. 10 / 10
| 10
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"Erythromycin suppresses poly I : C induced IFN-beta production by reducing TLR3 expression by monocyte derived dendritic cells [66]."
27468646
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"The Actinomycin D concentration used (1mug/mL) did not affect BMDM viability, but was sufficient to block de novo expression of IFNbeta in BMDM treated with poly I : C (XREF_SUPPLEMENTARY)."
23935197
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"XREF_BIBR Consistent with its inhibitory effect on poly I : C induced IFN-beta gene expression, PAR 2 AP also inhibited poly I : C induced TLR3 mRNA expression (XREF_FIG)."
19865078
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"Targeting RIG-I and MDA5 helicases by poly I : C transfection with a lipid carrier as reported by [XREF_BIBR], did not result in MHV mediated inhibition of poly I : C induced IFN-beta secretion."
22754655
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"Their studies pointed out that poly I : C induced IFN-beta was suppressed by pretreatment with monoclonal antibody to TLR 3."
15265658
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"When Trim65 -/- BMDMs were stimulated with cytosolic HMW poly I : C, LMW poly I : C, 5 '-triphosphate RNA (3pRNA, agonist for RIG-I), extracellular LPS (agonist for TLR4), or poly I : C (agonist for TLR3), only HMW poly I : C induced IFN-beta production was blocked as expected (XREF_FIG), confirming that TRIM65 is specifically involved in MDA5 activation."
28031478
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"The reduction of voluntary physical activity after poly I : C injection is independent of the effect of poly I : C induced interferon-beta in mice."
18191426
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"In addition, U0126 inhibited poly I : C induced IFN-beta, IL-6, and iNOS expression as well as induction of NO downstream of these cytokines."
23892079
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"A deficiency of PAR-1 was associated with significantly lower levels of poly I : C dependent induction of IFNbeta, IFNgamma, CXCL10, IRF7 and viperin but not CCL5 mRNA expression (XREF_FIG)."
27820939
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"As shown in XREF_FIG, only the p38 inhibitor (SB202190), but not ERK or JNK inhibitors (U0126 or SP600125), significantly inhibited poly I : C induced IFN-beta promoter activation."
23056170