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OTUB1 binds HIF1A. 12 / 12
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"OTUB1 interacts with HIF-1α."
35732631
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"To determine the effect of OTUB1 on HIF activity mechanistically, we next examined whether OTUB1 interacts with HIF-1α."
35732631
sparser
"Ectopic expression of OTUB1 interacted with ectopically expressed HIF-1α in HEK293T cells and vice versa (Fig. xref )."
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sparser
"In HEK293T cells, endogenous OTUB1 associated with endogenous HIF-1α (Fig. xref )."
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sparser
"Domain mapping indicated that ODDD domain, ID and CAD domains of HIF-1α had highest binding capability for OTUB1, but the N-terminal domain (bHLH) did not bind to OTUB1 and was not required for the interaction between OTUB1 and HIF-1α (Fig. xref , xref )."
35732631
sparser
"In HIF-1β -deficient H1299 cells ( HIF-1β −/− ), ectopic expression of OTUB1 interacted with ectopically expressed HIF-1α, indicating that hetero-dimerization of HIF-1α and HIF-1β is not required for the interaction between OTUB1 and HIF-1α (Fig. xref )."
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sparser
"In addition, it appeared that the N-terminal domain (E2/UBD) of OTUB1 did not bind to HIF-1α, while the C-terminal domain of OTUB1 had highest binding capability for HIF-1α (Fig. xref )."
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reach
"OTUB1 binds to HIF-1alpha and depletion of OTUB1 reduces endogenous HIF-1alpha protein under hypoxia."
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biogrid
No evidence text available
35732631
biogrid
No evidence text available
35732631
sparser
"OTUB1 binds to HIF-1α and depletion of OTUB1 reduces endogenous HIF-1α protein under hypoxia."
35732631
sparser
"Furthermore, our subsequent experimental studies revealed that OTUB1 can directly interact with HIF1α and remove ubiquitination modifications on HIF1α."
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