IndraLab

Statements

Escitalopram inhibits KCNH2. 5 / 5
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"The blocking of hERG by escitalopram was voltage dependent, with a steep increase across the voltage range of channel activation."
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"Both escitalopram and citalopram produced a reduction of hERG channel protein trafficking to the plasma membrane but did not affect the short-term internalization of the hERG channel."
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"Fluoxetine and its metabolite, norfluoxetine, citalopram and escitalopram prolong the QT interval by directly inhibiting the hERG potassium channels and by disrupting channel protein trafficking reducing the number of channels on the cell membrane [XREF_BIBR]."
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"Escitalopram block of hERG potassium channels."
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"These results suggest that escitalopram blocked hERG currents at a supratherapeutic concentration and that it did so by preferentially binding to both the open and the inactivated states of the channels and by inhibiting the trafficking of hERG channel protein to the plasma membrane."
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