IndraLab

Statements

USP9X activates YAP1. 6 / 6
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"A former report demonstrated that USP9X can modulate angiomotin (AMOT) family, including angiomotin like 2 (AMOTL2), to affect the phosphorylation and cytoplasmic sequestration of YAP1.27 28 To check whether USP9X could regulate AMOT or AMOTL2 to modulate YAP1, we then increased the expression of USP9X in VSMCs and decreased USP9X expression in PDGF-BB-treated VSMCs (Figures S3A and S3B)."
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"Moreover, overexpression of USP9X, dramatically increased YAP1 stabilization (XREF_SUPPLEMENTARY), while overexpression of the CS mutant decreased YAP1 stability."
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"In this study, we demonstrate that USP9X may target YAP1 for deubiquitination and stabilization, thereby promoting breast cancer growth and tumor progression."
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"Taken together, these results suggest that USP9X directly regulates YAP1 stability."
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"USP10 and USP9x have been shown to stabilize YAP by removing polyubiquitin chains, and ultimately mediate the aberrant activation of YAP and TAZ."
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"Mechanistically, it was found that hsa_circ_0024093 could regulate the expression of USP9X, which further induced YAP1 deubiquitination to stabilize YAP1 protein."
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