IndraLab

Statements

UCHL5 inhibits proteolysis. 9 / 9
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"The RNAi of UCHL5 or USP14 alone does not affect cell growth and proteasome composition but accelerates cellular protein degradation; however, RNAi of both UCHL5 and USP14 can inhibit cellular protein degradation."
26097878
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"Importantly, whereas knockdown of POH1 interferes with the proteasome assembly, depletion of either USP14 or UCH37 alone does not affect or even slightly enhances protein degradation rates."
26295307
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"In contrast, RNAi of either UCHL5 or USP14 alone did not affect cell growth, proteasome structure, or proteolytic capacity, but increased the rate of protein degradation."
29039082
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"Interestingly, b-AP15, a dual inhibitor of Usp14 and Uch37, was shown to prevent protein degradation and inhibit tumor progression in acute myeloid leukemia models [222]."
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"In contrast, RNAi of Uch37 or Usp14 had no detectable effect on cell growth, proteasome structure or proteolytic capacity, but accelerated cellular protein degradation."
18162577
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"Similarly, the target protein β-catenin is down-regulated, indicating that UCHL5 is likely to inhibit protein degradation through the classical deubiquitination pathway."
38773433
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"It is believed that Uch37/UCHL5 suppresses protein degradation by shortening the chains of inappropriately or poorly modified substrates ( Lam et al., 1997; Koulich et al., 2008 )."
25444757
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"It has been shown that UCHL5 controls proteasome function and inhibition of UCHL5 promotes protein degradation in autophagy XREF_BIBR."
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"RNAi of either Uch37 or USP14 (the mammalian homologue of yeast Ubp6) accelerates protein degradation."
19182904