IndraLab

Statements

D(pT)3 inhibits TLR7. 3 / 3
| 3
reach
"In this study we demonstrate that poly (T) ODNs can inhibit TLR7 and enhance TLR8 signaling events involving NF-kappaB activation in HEK cells and cytokine production (IFN-alpha, TNF, and IL-12) by human primary PBMC."
17114492
reach
"For example, poly (T) ODNs inhibited TLR7 activation but enhanced TLR8 signaling by imidazoquinoline derivatives optimized to trigger either TLR7 or TLR8."
28392787
reach
"Nevertheless, in combination with imidazoquinolines such as resiquimod or CL075, poly(dT) increases TLR8 mediated signaling and abolishes TLR7 mediated signaling [256,257]."
32203790