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OTUB1 activates HIF1. 5 / 5
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"By contrast, disruption of OTUB1 in H1299 cells caused a reduction of endogenous HIF-1α protein under hypoxia (1% O ) (Fig. 5C)."
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"In this study, we identified that OTUB1 is involved in regulating HIF-1α activity independent of PHDs/VHL and FIH, and disruption of OTUB1 reduces HIF-1α protein under hypoxia."
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"Given that the non-canonical activity of OTUB1 is suppressed by FIH under normoxia [59] and OTUB1 regulates HIF-1α via its non-canonical inhibition of ubiquitination, OTUB1 might contribute to the stabilization of HIF-1α protein under hypoxia."
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"Here, inferred from the modulation of OTUB1 by FIH, an important regulator of HIF pathway, we further identified when FIH loses its suppressive role on the non-canonical inhibition ubiquitination activity of OTUB1 under hypoxia, OTUB1 enhances HIF-1α activity, uncovering a connection among FIH/OTUB1/HIF-1α."
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"OTUB1 binds to HIF-1α and depletion of OTUB1 reduces endogenous HIF-1α protein under hypoxia."
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